Every good captain knows that when your ship is in distress, you send out an SOS. Now, two new papers now leave us wondering if that tactic is borrowed from diseased tissues. Many diseases are characterized by cell death that releases circulating cell-free DNA (cfDNA) into the blood stream, which can now be analyzed in […]
EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.
Sequencing technologies have created a dizzying number of opportunities for epigenetic researchers to explore questions that couldn’t be tackled before. Despite the immense power that sequencing delivers, though, the whole process still isn’t quite as simple as pushing a big red button, and watching the groundbreaking discoveries roll in. Even as sequencing becomes faster, easier, […]
RNA-protein interactions are key to understanding human health and disease. Crosslinking-immunoprecipitation (CLIP) and related technologies are powerful tools for characterizing these interactions. Since their introduction in 2008 (Licatalosi et al., 2008), CLIP-based approaches have been applied to prominent RNA research fields such as HIV and cancer. Recently, Sebla Kutluay and colleagues used CLIP to characterize […]
While the fashion and music tastes of the late 1980’s was rather questionable, it was a time of historic technological and societal change. Between the breakdown of the Soviet Union and the rise of the global computer network that we now call internet, a small group of researchers succeeded for the first time in generating […]
For centuries, some of the world’s leading scholars worked endlessly with one objective, to turn ordinary metals into gold. Now, scientists of the 21st century are trying their hand at another type of alchemy, turning one cell type into another. This process, known as ‘transdifferentiation’ or ‘direct reprogramming’ can create a potentially limitless source of […]