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Features

EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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Epigenetic Sequencing Woes Overcome by Services Know-how

Sequencing technologies have created a dizzying number of opportunities for epigenetic researchers to explore questions that couldn’t be tackled before. Despite the immense power that sequencing delivers, though, the whole process still isn’t quite as simple as pushing a big red button, and watching the groundbreaking discoveries roll in. Even as sequencing becomes faster, easier, […]

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Review: Crosslinking-Immunoprecipitation (CLIP) Methods

RNA-protein interactions are key to understanding human health and disease. Crosslinking-immunoprecipitation (CLIP) and related technologies are powerful tools for characterizing these interactions. Since their introduction in 2008 (Licatalosi et al., 2008), CLIP-based approaches have been applied to prominent RNA research fields such as HIV and cancer. Recently, Sebla Kutluay and colleagues used CLIP to characterize […]

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Keeping Tabs on Off-Target Effects of Genome Editing

While the fashion and music tastes of the late 1980’s was rather questionable, it was a time of historic technological and societal change. Between the breakdown of the Soviet Union and the rise of the global computer network that we now call internet, a small group of researchers succeeded for the first time in generating […]

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Cellular Transdifferentiation: Meet the 21st Century Alchemists

For centuries, some of the world’s leading scholars worked endlessly with one objective, to turn ordinary metals into gold. Now, scientists of the 21st century are trying their hand at another type of alchemy, turning one cell type into another. This process, known as ‘transdifferentiation’ or ‘direct reprogramming’ can create a potentially limitless source of […]

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Bacterial Kryptonite Uncovered in the Biological Dark Matter Mines

Public health has a looming, if slow-simmering, crisis. Antibiotics, which revolutionized health care in the 20th century, are losing their punch. Evolution, it turns out, is pretty effective at producing things that don’t die. Accordingly, bacteria are evolving resistance to our antibiotic arsenal, and more people are suffering from previously-treatable infections. Meanwhile, the pipeline of […]