Since 3’ UTRs were found to contain docking sites for miRNAs, labs with computational muscle around the world have been chipping away the target predication dilemma, but like any game, it’s hard to win when you don’t know the rules. It’s even harder when the rules are being rewritten weekly which is why we have […]
EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.
For years, transcriptional regulation took center stage in studies of gene expression, and the nuances of which transcription factor binds to which DNA sequence under which circumstances dominated the dialogue of molecular biologists. In recent years, a supporting actor has threatened to steal the show: enter, post-transcriptional regulation. The idea that messenger RNA utilization could […]
Since the advent of bisulfite conversion over 15 years ago, dozens of labs have streamlined the procedure, new patents have been filed, and numerous research kits with “new and improved” versions of the protocol have been launched, yet the core principal of the method remains the same: change a C to a U. Over the […]
George Adrian Calin received both his M.D. and Ph.D. degrees at Carol Davila University of Medicine in Bucharest, Romania, where he started cytogenetics work with Dr Dragos Stefanescu. After completing cancer genomics training in Dr. Massimo Negrini’s laboratory at University of Ferrara, Italy, he became a postdoctoral fellow at Kimmel Cancer Center in Philadelphia, PA, […]