Researchers have been puzzled by the discovery of several-kilobase-long, polyadenylated transcripts that overlap functional coding regions but do not themselves encode proteins. A recent Nature paper by Kouji Hirota, Kunihiro Ohta, and co-workers at the RIKEN Advanced Science Institute (Japan), the University of Tokyo, and Boston College indicates that some of these ncRNAs are transcriptional […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
Let’s face it: it’s an RNA world. In addition to RNA’s many genetic, catalytic, and structural roles, the discovery of small non-coding RNAs has unveiled an entire continent of epigenetic functions. Small RNAs act in processes such as mRNA destruction, translational inhibition, and DNA methylation. Now it appears that, at least in plants, small RNAs […]
Recent evidence has shown that the let-7 miRNA bites the hand that feeds it . . . and in an unconventional way. By searching for short sequences conserved at the nucleotide level in the coding regions of 17 species, Hilary Coller and co-workers at Princeton University identified three let-7 target sites within the coding sequence […]
It turns out that the small but mighty inhibitors of gene expression have an achilles heel and can be served up a taste of their own effect. Qihong Huang, Alexander Deiters, and colleagues at The Wistar Institute, North Carolina State University, and the University of Pennsylvania School of Medicine discovered the first small molecule inhibitor […]
If you’re looking to sneak your grant in on the earliest date for the Epigenomics of Human Health and Disease (R01) grant, time is ticking. Applications are being accepted starting this Sunday. That’s the right, the date says September 28th. For those of you looking for additional information, the grant information is listed below, but […]