The methylation of histones at specific sites has been linked to both transcriptionally active and repressive chromatin. However, the structural basis for these effects has been difficult to study because homogeneous populations of methylated histones were not available for x-ray crystallography. This situation changed recently with the development of a method to introduce modifications such […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
Human blood serum is cellular buffet of different biological molecules sampled continuously from every tissue of the body. So it’s not surprising that many researchers have attempted to identify biomarkers in serum that reflect a particular physiological or disease state. Most of these potential biomarkers are proteins (important-yes, exciting-not really), but Zvi Bentwich, Ayelet Chajut, […]
Some might recall playing with Mr. Potato Head as a child (or maybe earlier this morning). By sticking different noses, mouths, eyes, shoes, or other accessories on the basic potato head module, you could generate a variety of silly-looking spuds. Similarly, the interaction of different accessory proteins with the miRNA-argonaute complex might determine the fate […]
OK this one is a week old, but we love a paper that addresses epigenetic regulation of epigenetic regulators, so we couldn’t resist a recent PNAS report that identified a miRNA DNA methylation signature for human cancer metastasis. Like proteins, miRNAs act as oncogenes, tumor suppressors, and metastatic mediators, and their expression can be influenced […]
Gone are the days when microRNAs (miRNAs) were relegated to the unimportant “junk heap” of sequences cluttering up the genome. We now know that these tiny, highly conserved non-coding RNAs play important roles in RNA stability and translation by base-pairing with partially complementary sequences in the 3’ untranslated regions (UTRs) of target mRNAs. Moreover, a […]