Do you remember the name of your fourth-grade teacher? How about what you had for lunch last Thursday? Highschool Prom date? Yeah, we went stag too, but if you’re having a hard time remebering key events, ncRNAs may be to blame! The human brain expresses high numbers of ncRNAs, and mounting evidence indicates important contributions […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
Unfortunately, the KISS principle (‘keep it simple, stupid’) doesn’t apply to chromatin. Although we’d like to think that certain histone modifications are always “good” for gene transcription and others are invariably “bad,” Barbara Panning and co-workers at the University of California San Francisco have found that in embryonic stem cells (ESCs), the transcriptional outcome of […]
Everywhere you look, be it Science or Nature, US Weekly (OK, not quite), silencing by ncRNAs is making headlines. But the targets and mechanisms of this silencing are not always clear. A recent report by Peter Fraser and co-workers at The Babraham Institute (UK) and several other universities and centers in Japan and Europe has […]
A very difficult-to-treat childhood leukemia may benefit from the discovery of a small but potent epigenetic change that launches the cancer but could potentially be reversed relatively easily, preventing cancer-promoting genes from being turned on. Children with the subtype of acute lymphoblastic leukemia (ALL) known as MLL-AF4 have a cure rate of just under 50 […]
Like a conscientious librarian, miRNA can’t seem to resist saying “Shhhh!” whenever the opportunity arises, whether in post-transcriptional or, as a new study suggests, in transcriptional silencing of genes. Although miRNAs were initially thought to suppress gene expression primarily through translational inhibition, recent evidence suggests additional roles for miRNAs in regulating gene expression in the […]