No longer can the genetic and epigenetic causes of cancer and the resulting changes in gene expression be analyzed separately, with little regard for their interdependency. In this spirit, Jeremy Squire and coworkers at the Hospital for Sick Children, the Ontario Cancer Institute, and Queen’s University (all in Canada) conducted the first integrative analysis of […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
Last week PLoS Genetics ran a great paper from Anders Lindroth and colleagues illustrating a mutually exclusive relationship between DNA Methylation and methylation of H3K27 in the a differentially methylation domain (DMD) of an imprinting control region (ICR). Now before we drop any more epi-breviations…. The area of focus in the study was a […]
miRNAs, the small but mighty inhibitors of complementary mRNA sequences, might be accused of having a Napoleon complex, but they don’t start out life itty-bitty—they are transcribed as long primary miRNAs (pri-miRNAs). Cleavage by the RNase III-like enzyme Drosha in the nucleus releases a ~70-nt stem-loop structure (pre-mRNA), which is further processed by Dicer in […]
Let the blame game begin. In addition to our lifestyle habits, our mothers could have something to do with those stubborn pounds that dont seem to shed. An interesting obesity studying involving DNA methylation has provided new evidence suggesting that obese moms give birth to kids who have a propensity to become even more obese. […]
Not even a month after announcing a reagent supply agreement with OncoMethylome Sciences, LabCorp has announced the commercial availability of the Methylation-Specific PCR Assay for monitoring the methylation status of Vimentin DNA. Marketed as ColoSure(TM) by LabCorp, the MSP Assay is being positioned for assessing any stage colorectal cancer in asymptomatic average risk patients who […]