Some scientific breakthroughs are so transformative that there’s no containing their spread once they’ve seeded. By engineering cellular nuclear reactions with a biochemical twist, the most powerful deactivated Cas9 (dCas9) methyltransferase explodes from the lab of Tomasz Jurkowski at the University of Stuttgart. The free energy of this reaction forges not only a new tool […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
Once thought to be monogamous molecules characterized by devote linear relationships, chromosomes turn out to be philandering conformation-changers with burning loins of desire concealed between their genes. Coming from the lab of Bing Ren at the University of California, San Diego, a massive analysis of genome-wide chromosome interactions captured by Hi-C uncovers a distinct piece […]
There comes a time in every researcher’s career when you need to step up the throughput, but the thought of high throughput ChIP can be paralyzing. “How much sample is this going to cost me?” “What happens if something goes wrong…that’s 96 samples!” The first thing you want to look for when transitioning to high […]
It’s that time of year again: time to attempt the sisyphean task of maintaining peace between relatives who are constitutionally incompatible. Suppose you want both the uncanny gifting skills of Aunt Mildred and the mouth-watering cooking prowess of Uncle Frank. But if you allow them in the same room at the same time, both the […]
The old adage reads “you are what you eat”, but a tasty new study turned that bland old phrase into “your histones are what you eat!”, and what’s more, those behind the study have worked the mechanistic link. Some of our daily diet (i.e. coffee and candy) acts as an energy and carbon source for […]