The drivers of gene expression maintain a fragile balance that tends to cross the LINE in cancer. LINE-1s are transposable elements full of both mystery and regulatory potential. Within their 5’ untranslated region (UTR) lies a bidirectional promoter (L1-5’UTR) that consists of a sense promoter (L1-SP), which transcribes the element, and an antisense promoter (L1-ASP), which […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
Now that has spring has sprung, many of us are quickly remembering not only how much we missed the sunshine, but also that we forgot to stock up on aloe vera to soothe that fresh sunburn. Attesting to the utility of a good spot treatment, the lab of Yang Shi at Harvard Medical School reveals […]
The soaring Eiffel Tower in Paris, the tumultuous Guggenheim in Bilbao, or the intricate genome structure of a single cell; which architectural marvel impresses you the most? For the labs of Leonid A. Mirny and Kikuë Tachibana-Konwalski, the latter looms above any such extravagant edifice, but the available analytical tools lacked the resolution required for […]
Mapping an undulating, dynamic, and partially hidden landscape represents a vexing problem to say the least, especially when the landmarks of interest are rare DNA demethylation by-products in a single cell! This is the task faced by those intrepid explorers hoping to map the genome-wide location of 5-formylcytosine (5fC), a fleetingly rare oxidized form of […]
While chromosome conformation capture (3C) methods like single-cell Hi-C focus on coupled pairs of chromosome contacts, and even their promiscuous regions, candid snapshots of chromosomal threesomes have remained an intimate secret … until now. The genomic architects in the labs of Ana Pombo and Mario Nicodemi developed a new method and accompanying statistical model to […]