The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27me) via its catalytic subunit Ezh2. While H3K27me3 and H3K27me1 have been associated with gene repression and activation respectively, the exact role of H3K27me2 remains under-explored. However, recent works in temperature-sensitive drosophila and in PRC2 knock out embryonic stem cells (ESCs) suggest a role […]
- Stem Cells
Stem Cell Research Headlines
Get all the latest highlights from the literature and special features covering trending stem cell research and applications.
When it comes to gene therapy, blood diseases are prime candidates. Blood cells are constantly turning over, so you can quickly fix the blood supply if you replace the blood-producing stem cells in bone marrow; i.e., hematopoietic stem/progenitor cells (HSPCs). Transplanting marrow from a healthy donor is one approach, but a match can be difficult […]
Here at EpiGenie we like to think of ourselves as reporters of genomic methylation, but two new studies from the lab of Rudolf Jaenisch at MIT give us a run for our money and demonstrate the utility of their reporter of genomic methylation (RGM). Using RGM, the talented group brings forth a deeper understanding of […]
Mesenchymal stem cells (MSCs) are surely the “workhorses” of both the body and the regenerative medicine field. They display multiple advantageous characteristics, including the ability to differentiate into musculoskeletal tissues, that make MSCs the go-to cell type for tissue-engineering solutions for disease/age-related disorders. Furthermore, many tissues require the proper on-going function of tissue-resident MSCs to […]
The English sea captain and politician Sir Francis Drake believed in “sic parvis magna”, or “greatness from small beginnings”. While he hasn’t been around to see the recent explosion in organoid (or mini-organ) research, we are sure he would be impressed. Measuring a few millimeters in diameter and produced via three-dimensional differentiation of stem cells, […]