Tools are great for building, but sometimes it’s more fun using them to break things down. While we’ve applied deactivated Cas9 (dCas9) tools to build our knowledge of DNA methylation, this time it takes an entire toolbox to break the connection between histone methylation and gene repression. This constructive deconstruction comes at you from the […]
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Hacking the epigenome is no easy task. Each deactivated Cas9 (dCas9) system boasts its own nuances that must be teased apart before we can crack the histone code with its suite of effector domains. When it comes to histone acetylation, we’ve seen the histone acetyltransferase construct dCas9-p300, which writes H3K27ac to activate gene expression. However, […]
They help organize our schedules, they keep us in touch with good (and bad) friends, and they barely leave our sides throughout the day. But can we exploit the ubiquitous nature of smartphones to facilitate personalized treatment of human disease? This is the hope of researchers from the laboratory of Haifeng Ye (East China Normal […]
Yes, you read that correctly, researchers from the lab of Oliver G. Schmidt (IFW Dresden, Germany) have developed a half-biological, half-mechanical cancer-killing cyborg based on the humble spermatozoa. Specifically, the extremely virile research team loaded sperm with a cargo of chemotherapeutic drugs and provided each wriggler with a specially designed metallic harness to allow magnetic […]
Mmm… post-lunch blood glucose spike! Sitting down at my quiet computer, I can nearly hear my pancreatic islet cells working away, pumping out insulin to keep my blood glucose levels in check. Unfortunately, millions of people are not so well-protected from the glycemic havoc so mercilessly wreaked by chocolate cake. For people with type 1 […]