Some scientific breakthroughs are so transformative that there’s no containing their spread once they’ve seeded. By engineering cellular nuclear reactions with a biochemical twist, the most powerful deactivated Cas9 (dCas9) methyltransferase explodes from the lab of Tomasz Jurkowski at the University of Stuttgart. The free energy of this reaction forges not only a new tool […]
- Synthetic Biology News
Synthetic Biology Headlines
Get all the latest highlights from the literature and special features covering trending synthetic biology research and applications.
It’s that time of year again: time to attempt the sisyphean task of maintaining peace between relatives who are constitutionally incompatible. Suppose you want both the uncanny gifting skills of Aunt Mildred and the mouth-watering cooking prowess of Uncle Frank. But if you allow them in the same room at the same time, both the […]
CRISPR/Cas9 may be the flashiest gene editing tool out there right now, but there are certainly other contenders for that throne. We previously profiled Argonautes as one alternative; another is peptide nucleic acids, or PNAs. Like DNA, PNAs are strings of standard nucleotide bases, but instead of a charged phosphate backbone, they are held together […]
If there’s an official analogy for Cas9, it’s a pair of molecular scissors. Give Cas9 an RNA guide, and it will hunt down the complementary DNA and slice it in two with surgical precision. However, in this, the age of multitasking (HEY! Put down that other screen and pay attention!), being a one-trick pony doesn’t […]
In today’s world there’s not much you can be sure of, particularly when it comes to understanding the complexities of human cognition. Thankfully, the epigenome offers some much needed explanation, as demonstrated by the insight gained from DNA methylation maps of human neurodevelopment. However, genetic interactions created by 3-D chromosome structure have remained more of […]