• Technology


Keeping up with the rapidly evolving technology landscape for epigenetics and non-coding RNA research can be daunting. Learn more about the available methods out there and stay on top of the latest developments in our Technology section.


Webinar: Multiplex Profiling of Epigenetic Modifications – Measuring Assay Specific & Off-target Effects in the Same Sample

Multiplex Profiling of Epigenetic Modifications: Measuring Assay Specific & Off-target Effects in the Same Sample July 28th, 10:00am PST; 1:00pm EST Presented by Mary Anne Jelinek PhD Senior Research Scientist, Active Motif Register Now >>>   Abstract: A variety of epigenetic modifications including post-translational modifications (PTMs) on histone tails regulate gene expression and have profound effects on […]


Optogenetics Sets the Pace

When it comes to the fast pace of biotechnology, missing a beat is never good. Building on that principle, a talented team from Israel used optogenetics to resynchronize hearts with just that problem. Optogenetic systems are showing tremendous clinical potential, whether it be bringing eyesight to the blind or restoring excitable physiology, they offer a […]


Gene Editing Future Brightens with paCas9

We knew it was coming.  No, not another Jurassic Park sequel.  No, not another installment of Star Wars.  More inevitable than the revival of the Terminator franchise: we now have photoactivatable CRISPR/Cas9. Yes, as surely as the sun rises, scientists have developed a way to use that light (or at least the blue part) to […]


Locus-Specific Biochemical Analysis of Genome Functions Using enChIP with CRISPR

Abstract Elucidation of molecular mechanisms of genome functions such as transcription and epigenetic regulation requires identification of components mediating the genome functions. To this end, we recently developed the locus-specific chromatin immunoprecipitation (ChIP) (locus-specific ChIP) technologies to identify molecules interacting with a given genomic region of interest in vivo. Locus-specific ChIP consists of insertional ChIP […]


None Shall Pass! Genome Editing Stops Heritable Diseases in Their Tracks

The scientific world is still reeling from the news of the first genome editing of human embryos to treat genetic disease, as we have reported previously here on Epigenie. Unfortunately, the paper suggested that this strategy may need huge improvement or may never be applicable. However, another recently published study, from the laboratory of Juan Carlos […]