Usually, you don’t want your genome sequencing served up with a sugar coating; however, thanks to a clever a new 5hmC sequencing technique, we can indulge in some sweet single-cell and strand-specific insight. The study of 5hmC (5-Hydroxymethylcytosine) prevalence in DNA typically involves utilizing modified bisulfite sequencing, 5hmC specific antibodies, or restriction enzymes. Aba-seq makes […]
Keeping up with the rapidly evolving technology landscape for epigenetics and non-coding RNA research can be daunting. Learn more about the available methods out there and stay on top of the latest developments in our Technology section.
Navigating the epigenetic landscape is no easy feat. Clear markings and smooth rides through its canals can quickly give way to a hectic hodgepodge of mixed signals and uncertain routes. A great example is bivalent chromatin, which contains marks of both activation and repression. Characterized by Bernstein et al. in 2006, the most studied bivalent […]
Gene editing with CRISPR/Cas9 is here, there, and everywhere. We have seen gene editing in human somatic cells, pluripotent stem cells, and even embryos. However, we should also be looking at CRISPR-based gene editing somewhere else: in a living, breathing human. The question is – where does the current technology stand on the in vivo […]
They help cook dinner, clean the dishes, and sweep up afterward. They also build our cars, help us explore space, and now they may be on the verge of aiding in highly complex tasks in the laboratory. In particular, robot-based automation is being explored as a means to enhance efficiency in laboratories studying pluripotent stem […]
If a picture is worth a thousand words then surely a video must be worth more? So far, our knowledge about DNA methylation has been limited to a comic strip of static images at different stages. That may all be about to change with a new tool reported by the lab of Rudolf Jaenisch, which […]