Dr. David Gilbert discusses the ins and outs of 3-D chromosome folding, DNA replication and the highly dynamic cell nucleus. 3-D Chromatin and DNA Replication There’s no question. The thing that I’m most excited about is the uncanny alignment between three dimensional chromatin confirmation maps and replication timing. The alignment is the greatest alignment that […]
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Get up close and personal with some of the world's top epigenetics and non-coding RNA thought leaders.
Dr. Wolf Reik discusses the latest advances in epigenetic reprogramming, and what those new discoveries might lead to. The New DNA Methylation Landscape So it’s become apparent in the last two years, I guess, that there is this process of genome-wide epigenetic reprogramming which occurs naturally in germ cells, early embryo stem cells, et cetera, […]
Dr. Gerd Blobel discusses emerging techniques for visualizing the interactions of RNAs and chromatin. The Future of Chromatin Contact Analysis So there are other approaches that people are taking, which is: you use FISH, for example, Fluorescent In Situ Hybridization. And this is a method that can be used to validate interactions that have been […]
Dr. Steven Zeisel discusses how maternal intake of choline effects DNA methylation during development, and can lead to better memory. This interview was shot at the Keystone Symposia’s meeting on Nutrition, Epigenetics and Human Disease, 2013 held in Santa Fe, New Mexico Choline Metabolism, DNA Methylation, and Memory So I’m more and more believing that epigenetics […]
Dr. Frank Grosveld points out how little we actually know about the details of transcription and the molecular machinery involved. Transcription Factories We have this loop structure of the genome. And at the same time, we know that every gene that’s being transcribed, that’s active, is part of what we call transcription factories. So […]