Epigenetics is emerging as a fundamentally important area of biological and medical research with implications for our understanding of developmental and physiological processes, for childhood and adult disease, as well as for an unexpected and important new mode of inheritance. Epigenetics deals with changes in gene expression patterns that are independent of the underlying DNA sequence. These mechanisms modulate expression patterns throughout development and adulthood and are strongly influenced by both genetic and environmental factors. Anomalies can lead to birth defects, metabolic disease, cancer and behavioral changes. Recent evidence shows that epigenetic features can be transmitted across generations, suggesting that molecular changes in addition to DNA sequence differences control phenotypic variation and disease risk and therefore that epigenetics might be as important as genetics in organismal biology. We propose a program that brings together both established researchers and rising stars, where for the first time individuals focusing on molecular mechanisms can interact with those studying population consequences, so that these two communities begin to work together to understand epigenetics in the context of health and disease. We propose three themes, each with two sessions, and with two themes per day. Theme 1 is Epigenetic and Epigenomic Mechanisms; Theme 2 is Transgenerational Inheritance and imprinting, Theme 3 is Developmental Origins and Epigenetic Epidemiology. We propose 6 sessions, 2 per day over 3 days, with 7 speakers per day. Day 1: Session 1, theme 1 (4 speakers), Session 2, theme 2 (3 speakers) Day 2: Session 3, theme 2 (4 speakers), Session 4, theme 3 (3 speakers) Day 3: Session 5, theme 3 (4 speakers), Session 6, theme 1 (3 speakers) The final schedule of speakers will be determined by the appropriate sequence of hot topics at the time of the conference.
- Conferences
- Epigenetic Programming and Inheritance 2014
Epigenetic Programming and Inheritance 2014
Keystone Symposia - 06 Apr 2014
Summary
Topics
Details
Meeting Summary
Topics Include
- Epigenetic Mechanisms
- Epigenetics and GWAS
- Genome-Wide DNA Methylation
- Epigenetic Remodeling during Gametogenesis and Early Embryogenesis in the Zebrafish
- Mechanism and Reconstitution in vitro of Epigenetic Reprogramming in the Germ Cell Lineage in Mice
- Parental Origin Effects in Mouse
- Genomic Imprinting
- Methylation Establishment in the Germline
- Transgenerational Inheritance of Longevity
- Paternal Effects on Gene Regulation in Mammals
- Maternal Effects in Plants
- Heritable Epigenetic Changes
- Epigenetic Epidemiology
- Epigenetic Biomarkers and Causality in Complex Disease
- Epigenetic Trajectories to Neuropsychiatric Disease
- Epigenetics of Malnutrition
- Developmental (re)Programming by Endocrine Disruptors: Environmental Cross-Talk with the Epigenetic Machinery
Meeting Details
Date | 06 Apr 2014 |
Location | Boston Park Plaza Boston, Massachusetts, USA Get Directions |
Organizers | Joseph H. Nadeau, Marisa S. Bartolomei, Peter Gluckman and Wolf Reik |