These are exciting times for studying the structure and function of genomes and chromosomes. Detailed one-dimensional genomic maps of the promoters, enhancers or insulators, are being interpreted in 3D space to better understand the global regulation of the genome. As technology rapidly improves, it allows for finer genomic resolution, better quantitative readouts, and even single cell assays. The power of sequencing is combined with high-resolution microscopy to reopen the discussion on classical questions regarding the specificity and robustness of gene regulation, in a variety of cellular and developmental conditions. Finally, genome editing techniques are used to carefully dissect the genome and distinguish causal observations from correlative ones.
This meeting will bring together many of the leading experts on chromosome conformation and gene regulation for three days of focused discussions on the current challenges in the field.