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Neuropsychiatry and Inflammation: Epigenetic Target Discovery Beyond Oncology


Meeting Summary

Chromatin biology and epigenetics are exciting research fields at the frontier of modern biology, with considerable impact on fundamental mechanisms of human health and disease. This symposium aims to bring together clinical and preclinical scientists at the forefront of epigenetics and chromatin biology, inflammation, and neuropsychiatry research to discuss the latest advances in the field.

Following the recent successes in oncology, epigenetics research is now opening a new range of promising opportunities in inflammation and neuropsychiatry. We aim to explore future trends in epigenetics and related fields of gene regulation, development, molecular recognition and signalling, with an emphasis on prospects of translation into clinical applications.

Topics Include

Session 1: Epigenetics, Chromatin Biology and Human Disease

Chair: Cheryl Arrowsmith (SGC, Toronto, Canada)
9:50 – 10:20
Karin Michels (Harvard University, Boston, USA): Considerations in Study Design and Analysis of Epigenetic Mechanisms in Health and Disease
10:20 – 10:50
Arturas Petronis (U of Toronto, Canada): Epigenomics of Complex Neuropsychiatric Disease
10:50 – 11:20
Coffee Break
11:20 – 11:50
Giuseppe Testa (Eur. Inst. Oncology, Milan, Italy)
11:50 – 12:20
Hinrich Gronemeyer (IGBMC, U of Strasbourg, France)
12:20 – 12:50
Chris Ponting (U of Oxford, UK): Shining a light on ‘dark matter’ genes: molecular mechanisms of lncRNAs
Lunch: 12:50 – 13:50

Session 2: Inflammation

Chair: Marc Feldmann (Kennedy Institute, Oxford, UK)13:50 – 14:00Marc Feldmann (Kennedy Institute, Oxford, UK): Overview
14:00 – 14:30
Christopher Glass (UC San Diego, USA): A genome-wide view of macrophage activation
14:30 – 15:00
Gioacchino Natoli (Eur. Inst. Oncology, Milan, Italy): The macrophage epigenome and the control of inflammatory gene expression
15:00 – 15:30
Coffee Break
15:30  – 16:00
Laurens Kruidenier (GlaxoSmithKline, Stevenage, UK): Unlocking histone lysine demethylases as epigenetic drug targets
15:50 – 16:20
16:20 – 16:50

Session 3: Neuropsychiatry

Chair: Andre Fischer (DZNE, Göttingen, Germany)9:00 – 9:30
Wolfgang Wurst (Helmholtz Centre, Munich, Germany): TBC
9:30 – 10:00
Li-Huei Tsai (MIT, USA): Epigenetic mechanisms regulating neuronal plasticity gene expression and memory formation
10:00 – 10:30
Coffee Break
10:30 – 11:00
11:00 – 11:30
André Fischer (DZNE, Göttingen, Germany): Defining Epigenetic Disease Signatures for treating Brain Diseases
11:30 – 12:00



Meeting Details

Date14 Mar 2013
LocationSaid Business School
Oxford, UK
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OrganizersUdo Oppermann (SGC/NDORMS, Oxford), Chas Bountra (SGC, Oxford), Wen Hwa Lee (SGC, Oxford), Joanna Zapisek (SGC, Oxford) Hannah Lingard (SGC, Oxford)