Noncoding RNAs represent a diverse family of regulatory transcripts that affect every stage of gene expression, from transcription and mRNA stability to mRNA translation. Recent evidence has uncovered critical roles for noncoding RNAs in cancer pathogenesis. For example, hyperactivity or diminished function of specific microRNAs has been shown to drive tumorigenesis in human cancer cells and mouse models. More recently, long noncoding RNAs (lncRNAs) have also been linked to cancer phenotypes. Further establishment of the molecular functions of the myriad classes of noncoding RNAs, and the roles of these transcripts in development and physiology, will be essential for achieving a robust understanding of their roles in human malignancies.
This AACR Special Conference will provide a venue for presentation of the latest research related to all aspects of noncoding RNA biology and will include a strong component focused on the translational implications of noncoding RNA research for the development of new biomarkers and therapeutic strategies for cancer. The program will be of interest to basic and translational researchers in academia as well as those working in the pharmaceutical and biotechnology industries.