As a post-doctoral fellow in 1997, Karolin Luger burst onto the chromatin scene with the now classic Nature cover story, “Structure of the nucleosome core particle at 2.8 Å resolution” [Nature 1997, 389, 251−260]. A native of Austria, Dr. Luger joined the faculty at Colorado State University in 1999, where she is an HHM Investigator. […]
Epigenetics and ncRNA Headlines
Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.
In 1967, Joan Argetsinger Steitz received her Ph.D. from Harvard University, where she conducted her doctoral research on RNA bacteriophage in the lab of Dr. James Watson. As a post-doc at Cambridge, Dr. Steitz studied ribosome binding sites in mRNA. In 1970, she joined the faculty at Yale and began her groundbreaking and now famous […]
Gone are the days when microRNAs (miRNAs) were relegated to the unimportant “junk heap” of sequences cluttering up the genome. We now know that these tiny, highly conserved non-coding RNAs play important roles in RNA stability and translation by base-pairing with partially complementary sequences in the 3’ untranslated regions (UTRs) of target mRNAs. Moreover, a […]
No longer can the genetic and epigenetic causes of cancer and the resulting changes in gene expression be analyzed separately, with little regard for their interdependency. In this spirit, Jeremy Squire and coworkers at the Hospital for Sick Children, the Ontario Cancer Institute, and Queen’s University (all in Canada) conducted the first integrative analysis of […]
Last week PLoS Genetics ran a great paper from Anders Lindroth and colleagues illustrating a mutually exclusive relationship between DNA Methylation and methylation of H3K27 in the a differentially methylation domain (DMD) of an imprinting control region (ICR). Now before we drop any more epi-breviations…. The area of focus in the study was a […]