Researchers have been puzzled by the discovery of several-kilobase-long, polyadenylated transcripts that overlap functional coding regions but do not themselves encode proteins. A recent Nature paper by Kouji Hirota, Kunihiro Ohta, and co-workers at the RIKEN Advanced Science Institute (Japan), the University of Tokyo, and Boston College indicates that some of these ncRNAs are transcriptional […]
Epigenetics and ncRNA Headlines
Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.
Let’s face it: it’s an RNA world. In addition to RNA’s many genetic, catalytic, and structural roles, the discovery of small non-coding RNAs has unveiled an entire continent of epigenetic functions. Small RNAs act in processes such as mRNA destruction, translational inhibition, and DNA methylation. Now it appears that, at least in plants, small RNAs […]
Recent evidence has shown that the let-7 miRNA bites the hand that feeds it . . . and in an unconventional way. By searching for short sequences conserved at the nucleotide level in the coding regions of 17 species, Hilary Coller and co-workers at Princeton University identified three let-7 target sites within the coding sequence […]
A sensitive new nanotechnology assay might represent a “quantum leap” in DNA methylation detection. The technique, which was developed by Vasudev Bailey and co-workers at The Johns Hopkins University School of Medicine, uses quantum dots-fluorescent nanocrystals of a semiconductor material-to selectivel detect and quantify minute amounts of methylated DNA. As in methylation-specific PCR (MSP), sample […]
It turns out that the small but mighty inhibitors of gene expression have an achilles heel and can be served up a taste of their own effect. Qihong Huang, Alexander Deiters, and colleagues at The Wistar Institute, North Carolina State University, and the University of Pennsylvania School of Medicine discovered the first small molecule inhibitor […]