EpiGenie Stem Cell Epigenetics Review

We’re big fans of stem cell research, the vast potential it represents and the close connection it has to epigenetics. Apparently we aren’t alone either, judging by the avalanche of top-notch papers that regularly cross our monitors. We’ve even give serious consideration to launching another site just to be able cover the area properly (StemGenie, anyone?). But, until we can drum up the bandwidth to pull that off, take a look back at all of the stem cell related content we’ve covered.

Epigenetics of (iPS) Induced Pluripotent Stem Cells

5-Hydroxymethylcytosine in Stem Cells

Epigenetics of Differentiation and Stem Cell States

  • Two ES Cell Types Find Some Common Ground: There are few differences between nuclear transfer-derived ES (ntES) and in vitro fertilized embryo-derived ES (IVFES) cells. Sure, they’re from different sides of the ES cell tracks, but as researchers found out, once they’ve differentiated it hardly seems to matter.
  • To “B-cell” Or Not To “B-cell” – DNA Methylation & Stem Cell Fate: Recent work revealed some of the first insights into the causal relationships between methylation state and stem cell fate through a novel genetic approach allowing for tissue- and cell-specific shutdown of DNMT1.
  • miR-200a Takes Down Cancerous Stem-like Transition: Epithelial-mesenchymal transition (EMT) the gateway between normal epithelial cells and those that gain mesenchymal properties, is thought to be the point where cancer metastasis kicks off, and it seems that miRNA-200a runs the show when it comes to keeping that dangerous transition in check.
  • The Ups and Downs of miR-145 and OCT4 in hESCs: The intricate network of factors that allow stem cells to retain their stemness , like the transcription factors OCT4 and SOX2, and miRNAs, exhibit unique/different expression patterns in hESCs vs. differentiated embryoid bodies (EBs).
  • ESC Pluripotency Players Take To REST: The lab gloves came off in a recent Nature exchange on the putative role of the transcriptional repressor, REST, in embryonic stem cell pluripotency. Both groups cited previous findings that supported their data, making a compelling story for each.
  • Stem Cells Can’t Hold Their Liquor: Scientists determined that not only does alcohol change methylation patterns, but it blocks the necessary methylation programming changes that normally occur as NSCs differentiate.