For all we know about miRNA – how it’s made, what it does, how it folds, … – comparatively little is known about how the Argonaute (Ago) proteins allow miRNA to do what it does. Yet thanks to a group out of Germany, we now understand a bit more of the machinery that lets miRNA […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
Researchers in Boston figured that maybe they could find something interesting in all the non-protein, non-miRNA, non-siRNA genes. They did…linc-RNAs. Through a massive sequencing of ChIP data they uncovered a chromatin “signature” for actively transcribed regions between known protein coding genes, and used this signature to identify about 1700 previously un-annotated stretches of the genome at […]
Conventional wisdom had it that once a methylated repeat sequence is heavily demethylated, there’s no turning back. Not only don’t they become remethylated, but subsequent generations inherit the epigenetic changes as well. But a group of European researchers have found that this isn’t always the case and there are at least two distinct classes of […]
Imagine that you could go back in time and analyze the DNA methylation profiles of long-ago cancer samples (not to mention recession-proof your investment portfolio). EpiGenie can’t help with the latter because our time machine is on the fritz, but we can tell you about a new study in which researchers profiled the methylomes of […]
Between reading Dilbert cartoons and refilling their Swingline staplers, many of corporate America’s finest day dream of holidays to distant islands, but they’re not alone. Researchers studying DNA methylation have made minimal attempts to hide their infatuation with CpG islands, after all, these regions tend to associate themselves with prestigious protein-coding regions of genes. An […]