On any good pirate map, ‘X’ marks the spot for buried treasure. It turns out the same is true in epigenetics: xQTL analysis marks the spot for buried GWAS associations. Genome-wide association studies (GWAS) have been instrumental in identifying single nucleotide polymorphisms (SNPs) associated with human disease. However, finding the biological relevance of such SNPs […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
With age comes wisdom, and also a changing methylation landscape. These changes in methylation can predict life expectancy, with a subset referred to as the ‘epigenetic clock’. For those of us looking to add more time, caloric restriction has been shown to increase life expectancy and reduce the incidence of age-related diseases. Despite three decades […]
While plastic is fantastic, the luxury of our synthetic world comes at a price: plasticizing agents can affect our chances of bringing new life into that world thanks to our environmentally-responsive sperm. Phthalates, which are common plasticizing agents, disrupt the endocrine system and are present in food packaging, personal care products such as shaving cream, […]
Once a rock star makes it big, they treat the world to a tour. However, DNA methylation, being both an epigenetic rock star and an unbearable diva, has been more than fashionably late to the party! But fear not! DNA methylation has made a comeback with a hit record of scientific insight into human diversity. […]
While most studies on the N6-methyladenosine (m6A) RNA modification have been on the straight and narrow, the research trajectory taken by the labs of Cosmas C. Giallourakis and Alan C. Mullen will have you running around in circles! More specifically, Chan Zhou and Benoit Molinie (along with their tight circle of friends) sought to discover […]