Until now. DNA (cytosine) methylation, or the “fifth base” as many molecular biologists so fondly refer to it today, is not only breaking these rules, but might be behind breaking chromosomes and the accepted dogma of gene regulation.

Although the original genome sequencing project had a great plot (a heated race between private sector and government, Nature vs. Science) and a thrilling ending, it forgot one critical base in its haste.  The previews of the Epigenome Project have all the ingredients of a true masterpiece: three up and coming players in a classic plot composed of twisting DNA and secret codes.  Not bad for a sequel or for a “fifth base.”   What role will methylation play?  Our crystal ball at EpiGenie is broken, but you can bet we’ll be following the best of the best to keep you up to date.