- CpG WIZ® Amplification Kits

ools for Measuring Levels of Silencing-associated CpG Methlyation in DNA at Specific Genes Features Detect definitive changes in the CpG methylation pattern of genomic DNA Correlate transcriptional regulation with changes in methylation pattern Investigate epigenetic mechanisms of developmental control and disease progression Advantages Flexibility of experiment with a universal method for any gene of interest [...]

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- CpG WIZ® Fragile X Amplification Kit

Methylation of cytosines located 5′ to guanosine is known to have a profound effect on the expression of several eukaryotic genes (Bird, 1992). In normal cells, methylation occurs predominantly in CG-poor regions, while CG-rich areas, called CpG islands, remain unmethylated. Aberrant methylation of normally unmethylated CpG islands has been documented as a relatively frequent event [...]

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- CpG WIZ® MGMT Amplification Kit

Methylation of cytosines located 5′ to guanosine is known to have a profound effect on the expression of several eukaryotic genes (Bird, 1992). In normal cells, methylation occurs predominantly in CG-poor regions, while CG-rich areas, called CpG islands, remain unmethylated. Aberrant methylation of normally unmethylated CpG islands has been documented as a relatively frequent event [...]

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- CpG Wiz® p16 Amplification Kit

Expression of p16*, a tumor suppressor gene, is repressed in a variety of cancers such as bladder, colon and retinoblastoma. Methylation of CpG islands in the p16 promoter has been shown to be responsible for inactivation of this gene in certain cases. The CpG WIZ® p16 Amplification Kit is used for determining the methylation status [...]

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- CpG Wiz® Prader-Willi/Angelman Amplification Kit

A differentially methylated site exists in the CpG islands of SNRPN (small nuclear ribonucleoprotein-associated polypeptide N), a candidate gene for Prader-Willi/Angelman Syndrome. Normally, this site is methylated and inactive on the maternal homolog and unmethylated and transcriptionally active on the paternal homolog. In research samples from Prader-Willi individuals, only the methylated allele is present, while [...]

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