Loyal A. Goff, Ph.D presents his research on: Genetic Analysis of the Physiological Roles for lncRNAs in Development Abstract: Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological […]
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Dr. Alexander Meissner discusses the roles of epigenetic mechanisms in stem cells and development. Cytosine methylation in mammals is an epigenetic modification that is largely restricted to CpG dinucleotides and serves multiple critical functions including stable repression of target promoters, maintaining genomic integrity, establishing parent-specific imprinting patterns, and silencing endogenous retrotransposon activity. In somatic tissues, […]
Covering all the Bases with Genome-Wide 5-mC and 5-hmC Sequencing By Dr Keith Booher, PhD. Manager of Epigenetic Services at Zymo Research Abstract: There is an ever-increasing appreciation for the remarkable ability of epigenetic modifications, such as the methylation of cytosines in DNA (5-mC), to respond to environmental cues and influence gene expression in biological […]
Dr. Patrick Stover, PhD, the Director of the Division of Nutritional Sciences at Cornell University, provides a great overview of the key role of folate in one-carbon metabolism, and DNA methylation in nutrition. Folate, Nutrition, and DNA Methylation Regulation There’s a long history in the whole field of folate metabolism, one-carbon metabolism, that outcomes […]
Dr. Paul Soloway, PhD discusses his latest work on technologies that enable the interrogation of epigenetic marks on a single molecule. Epigenomic analyses are used for many applications, including discovering gene regulatory mechanisms; characterizing non-genetic transmission modes of adaptive and disease traits; identifying and detecting disease biomarkers; and for drug discovery, as epigenome modifying therapeutics […]