Developing Technologies for Improved In Vivo Epigenetic Imaging/AnalysisDecember 15, 2009The NIH is opening up its wallet again for epigenetic technology development. $3.5M will be allocated in 2010 for developing in vivo epigenetic imaging and analysis technologies. According to the grant description, the NIH has recognized that “… the technologies available to determine the epigenetic state of tissues in vivo are extremely limited. The specific […]
Targeted Bisulfite Sequencing with Padlock ProbesDecember 8, 2009A rising star in the epigenetics field, Dr. Kun Zhang joined the UCSD faculty in 2007 after a post-doc with George Church at Harvard. Engaging in a little friendly competition with his former mentor, Zhang published a technique for targeted bisulfite sequencing using padlock probes (Nat. Biotechnol. 2009, 27, 353) at the same time the […]
Bulletproof Your Bisulfite Conversion: Key Considerations from the ExpertsDecember 1, 2009There’s a lot of talk out there about bisulfite conversion, how useful it is, how it’s the “Gold Standard,” how laborious it is, how rough it is on your samples, but the reality of it is that there probably isn’t any better way to prep your samples for single nucleotide resolution methylation profiling, so don’t […]
MBD-Sequencing: The Latest Methylation Analysis Cocktail DeliversNovember 17, 2009Add 1 part enriched methylated DNA to 2 parts sequencing lanes, and you have a cocktail that delivers key insights without a data hangover. Last week, a team of Ohio scientists added the latest research recipe that is destined to become a lab fav in Nucleic Acids Research. The crew took the benefits of methylation […]
Stressing Out Over MethylationNovember 11, 2009Traumatic events like getting picked last for Dodgeball in gym class can really mess with your head. And some previous research has shown that really devastating incidents, such as 9-11, can change us, even while still in the womb, as shown in this video clip we posted a while back from the PBS Ghost in […]
