Cutting Through the Smog of Mitochondrial DNA Methylation after Prenatal Pollution ExposureAugust 7, 2020While everyone loves hearing about a scientific controversy, clearing the air can also provide a sense of satisfaction. So, sit back and take a breath of the fresh air that an environmentally conscious team brings to the controversy surrounding mitochondrial (mt)DNA methylation through their examination of prenatal exposure to environmental stressors such as air pollution […]
Common DNA Methylation Aging Profiles Convert Dog to Human Years Better Than EverJuly 20, 2020They say you can’t teach an old dog new tricks, but it turns out you can use new epigenomic tricks to tell you how old a dog is. The heuristic that to get a dogs age in human years, you multiply by seven is a little simplistic, and due for an update using epigenomic insights. […]
Filling in the Blanks: DNA Methylation-Dependent Glycosylation of Chromatin Modifiers Represses TranscriptionJuly 7, 2020You might think our portrait of the marks that make up the epigenetic landscape is nearing completion, but a new feature is now filling in some of the blank space behind a key regulatory mechanism. It has been long known that DNA methylation represses transcription via the recruitment of methylation-dependent repressive factors. The components of […]
Disrupted LADs Drive Epigenetic Alterations in Human Early-onset AgingJune 22, 2020The “driver” represents a crucial part of a successful Formula One team, a decent score at golf, and even a well-planned bank heist (!), and working out those factors that drive the onset of various diseases and disorders may provide critical mechanistic insight and even aid the development of novel therapeutic approaches. In the early-onset […]
Epigenetic Hole-in-One: Methylation of a Single CpG Disrupts GATA-1 Binding and Regulates Gene ExpressionJune 11, 2020The GATA-1 transcription factor is like the Tiger Woods of the erythroid cell lineage, topping the leaderboard and driving the expression of important developmental genes. Other molecular competitors, like the NuRD complex, are already on the course, but a new study shows how methylation of a single CpG is able to score a hole-in-one to […]
