Cell Surface Protein Profiling Gives Single-cell CUT&Tag a Pro UpgradeApril 25, 2022Nothing beats a Pro upgrade, and lately, researchers have given CUT&Tag the deluxe treatment. This chromatin profiling method received its first improvements with the releases of scCUT&Tag and then Spatial-CUT&Tag; now, we’ve been treated to a view of the cell surface protein profile in its latest form. A pro team of single-cell explorers from the […]
Single-cell Based DNA Methylation Deconvolution Method Scores Another Goal for EpigeneticsApril 25, 2022You might think you know the leading players in the field of computational epigenetics; however, each new season brings forward a squad of exciting new players eager to prove their worth. Recently, one of these players EpiSCORE-d the goal of extending in silico cell-type deconvolution of human epigenomic data to many tissues. While reference-based cell-type […]
APOE Tips Heterochromatin Balance Towards Stem Cell Senescence and AgingApril 11, 2022Like a healthy balance between work and play can enhance our day-to-day lives, a new study suggests that stem cells require a healthy epigenetic balance between silent and active chromatin domains to support their ongoing normal functions. More specifically, researchers headed by the well-balanced quartet of Moshi Song, Weiqi Zhang, Jing Qu, and Guang-Hui Liu […]
Has Cannabis Gone Up in Smoke? – Study Links Use to Accelerated Epigenetic AgingMarch 31, 2022Like there is no smoke without fire, another study has linked cannabis use to unwanted epigenetic alterations. We’ve seen that cannabis exposure alters DNA methylation in prenatal mouse brains (influencing subsequent behavior), the sperm of rats and humans (priming an autism spectrum disorder-like profile), and human adult brains (impacting brain function), and now epigenetic aging […]
DNA Methylation Provides New Insight into the Missing Heritability of ALSMarch 31, 2022The devastating and fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS) has an estimated heritability rate of around 50%, suggesting that a considerable portion of disease risk derives from environmental and lifestyle risk factors that can leave their mark on the epigenome. Can DNA methylation analysis provide new insight into the missing heritability of ALS? In […]
