miRNAs Get Well Deserved PromotionApril 30, 2009Since we launched EpiGenie, we’ve always considered ourselves big promoters of miRNA. Sure, we cover the big headers in chromatin and DNA methylation too, but it’s hard not to identify with these small, overlooked contributors… (OK enough with our high school sports sob stories). Once again we’ve been humbled by Mother Nature as a novel […]
The Ups and Downs of miR-145 and OCT4 in hESCsApril 30, 2009Human embryonic stem cells (hESCs) are delicate little creatures. Left to their own devices – especially in culture — they want to differentiate or die. By now you’ve probably heard of the intricate network of factors that allow these cells to retain their stemness – some, like the transcription factors OCT4 and SOX2, prevent differentiation […]
Fine-Tuning mRNA Deliveries with Alternative PolyadenylationApril 28, 2009The US Post Office tried it a few years back when they added those four extra digits onto our zip codes, allowing advertisers to target us with SPAM with utmost precision. At EpiGenie, we too, are always looking for simpler ways to pass along targeted information (RSS feeds, telepathy etc.,) to an ever-increasing population of […]
Polycomb and Trithorax Proteins Dominating the In CrowdApril 23, 2009At EpiGenie, we do our best to keep up with the latest research trends in the epigenetics scene so we couldn’t help but notice that lately, the Polycomb (PcG) and Trithorax (TrxG) proteins are grabbing more headlines than Octa-Mom. Deservingly so, when you consider the critical role these developmental switchboards play in maintaining expression patterns […]
Mining the TranscriptomeApril 17, 2009As the herculean genome sequencing efforts closed in on a draft of the human genome sequence back in 2000, the estimated numbers of “genes” that comprised our genome dropped quicker than the market cap of the biotech heavy Nasdaq after Clinton/Blair announced the sequences of these little gems would reside in the public domain. Shortly […]
