epigenetics

Epigenetics and ncRNA Headlines

Get all the latest highlights from the literature and special features covering trending epigenetics, ncRNA, and gene regulation research.

Search Articles

A “Batty” New Epigenetic Clock Provides Clues About Healthy Aging

April 8, 2021

Are you cuckoo for clocks, dotty for DNA methylation, and avid about aging? Well, a “batty” new study of epigenetic aging in certain long-lived winged mammals has just added to the zoo of clues about epigenetic age by providing a bat epigenetic clock. Specifically, an ardent team of researchers led by the levels heads of […]

From Single Molecules to Single Cells: NanoMethPhase and scMspJI-seq Upgrade DNA Methylation Mining Methods

April 2, 2021

Mining the DNA methylome can provide a treasure trove of biological insight, and two new whole-genome DNA methylation sequencing methods have come along to fuel a technological gold rush. NanoMethPhase and scMspJI-seq break new ground in phasing allele-specific methylation (ASM) and generating strand-specific single-cell methylomes. By applying these novel approaches, the talented teams dig deep into complex DNA […]

The Solution to Stop Stress Susceptibility: Spiny Neuron Histone H3K79me2 Modifications

March 29, 2021

Many of us dream of a quick fix to being so stressed all the time, and now that reality may not be so far off thanks to the identification of a histone modification behind the life-long effects of early-life stress (ELS). The nucleus accumbens is a brain region important for dopamine signaling and reward behavior. […]

Cancer-associated Histone Mutations Modulate Nucleosome Remodeling to Get That Histone Body Moving!

March 26, 2021

While any new study mentioning histones generally gets our epigenetic tails wagging, a stunning study into how cancer-associated histone mutations influence nucleosome remodeling has also got our “globular” bodies moving! Although most researchers focus on mutations in the histone tail, most high-frequency cancer-associated mutations actually affect the main “bodies” of the histone proteins (known as […]

AtacWorks: Deep Learning Levels Up ATAC-seq with Graphics Processing Units

March 19, 2021

It turns out that those graphics cards in our computers aren’t just great for gaming, they can also push your epigenomic research to the next level. When industry meets academia, we can all win and thanks to an exciting collaboration between the graphics processing unit (GPU) inventors at NVIDIA and the lab of ATAC-seq inventor […]

The Epitranscriptomic Results Are In: To Be Queen Bee, First Eat the Royal Jelly

March 19, 2021

It must be jelly, royal jelly. Giving new meaning to the adage “you are what you eat”, exciting epitranscriptomic findings have us buzzing about how diet influences larval development and royal status in honeybees. In a process known as caste differentiation, female honeybees fed different diets become either sterile workers or fertile queens. These bees […]

A Pre-emptive Epigenetic Strike Can Stop Transplants from Going Viral!

March 10, 2021

While social media mavens may consider “going viral” the zenith of their existence, latent virus reactivation represents a significant cause of morbidity and mortality in transplant patients. Now, in an extremely “likable” study, a tweetable team of researchers has described how epigenetic inhibitors may be an efficient means of selectively purging viral reservoirs before transplantation […]

Diet Adds a Tasty New Plot Twist in The Tale of Paternal H3K4me3 Transmission

March 2, 2021

The genetic tale of transgenerational epigenetic inheritance has just received a tasty twist in its latest installment focused on intergenerational effects. The latest story of this cereal … serial reveals how folate deficiency in the paternal diet influences embryonic development through H3K4me3 transmission. In a previous study, the lab of Sarah Kimmins (McGill University, Montreal, Canada) examined a mouse […]

dCas9-dMSK1 Provides the Potent Power of Programmable Histone Phosphorylation

February 20, 2021

Time to move over histone methylation, the potent activating power of programmable histone phosphorylation joins the dCas9 epigenome editing toolbox and shows how it takes histone acetylation along for the ride. A rather active team of researchers led by Isaac B. Hilton (Rice University, Houston, TX, USA) knew that phosphorylation represents one of the most […]

Stat3 is a Mitochondrial Mastermind Behind Metabolic Control of DNA Methylation in Naïve Stem Cells

February 15, 2021

We’ve seen that mitochondria can modify nuclear DNA methylation, but until recently, the identities of the masterminds behind how the powerhouse of the cell can affect epigenetic change in the nucleus have remained classified. Although Stat3 is most notably recruited by LIF to activate the pluripotency gene network in the nucleus, we also know that LIF […]