This meeting will focus on how metabolism can directly affect epigenetic regulation, and vice versa. It will bring together leading experts and newcomers to the field, to provide an important forum for fostering new ideas and collaborations.
The landscape of epigenetic modifications in any cell type is a snapshot of its metabolic status, since all modifications use metabolic intermediates as substrates or co-factors for chromatin-modifying enzymes. Interconnected questions at the frontiers of the fields of metabolism and epigenetics will be addressed: what are the molecular connections between metabolism and chromatin modifications, and how does dysfunction of these processes result in various diseases? What are the metabolic signals for relaying the cytoplasmic signalling to chromatin remodelling? How do cells sense and respond to environmental cues (e.g. nutrition) through epigenetic modifications, and what are the consequences for cellular metabolism? How does the differential use of epigenetic modifications regulate gene expression as a response to metabolic changes and differentiation programmes?