Presenter: Silvana Konermann, Graduate Student in Dr Feng Zhang’s Lab at Massachusetts Institute of Technology Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. The ease and scalability of the CRISPR-Cas9 system potentially enables systematic, genome-scale perturbation, but the magnitude of transcriptional up-regulation achieved by the first generation of Cas9 transcriptional […]
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Over the years, bisulfite conversion has become the most widely used method for DNA methylation analysis. It is the most convenient and effective way to map DNA methylation to individual bases. As the first step in numerous downstream analysis techniques, it is absolutely critical that the bisulfite conversion process is understood and performed well. Our […]
In this webinar, Dr. Xi Chen takes publicly available real ChIP-seq data sets to show you how to perform ChIP-seq routine analysis using a combination of different online tools available. This provides an opportunity for bioinformatics beginners and wet-lab biologists who do not have much experience with unix operating systems to have an idea about […]
Since its inception, the field of genetic engineering has introduced DNA to plenty of nips, tucks, and modifications all in the name of science. The latest evolution of these, genome editing, might be the most promising. Follow our favorite highlights in this rapidly moving application.
Life is complicated. While that does apply to ordering your daily caffeine fix at Starbucks, what we’re talking about here is darwinian, entropy-defying, self-replicating life. Just to store, read, and apply genetic information requires 3 different types of molecules: DNA, RNA, and proteins. That makes it tough to imagine how life could ooze into being in […]