Do you dread launching your next DNA methylation study with the same old affinity reagents? Worried that it’ll take too much time, or that the specificity just won’t hack it? Then fret no more, because the latest EpiMark™ DNA Methylation Enrichment Kit from New England Biolabs is here to offer a much more fulfilling experience.
DNAm Enrichment That’s Not Afraid To Be Sensitive
The EpiMark™ Kit’s driving force is the unique methylation capture reagent found in every box. It fuses MBD2a binding domains to IgG1 Fc tails, which are then attached to Protein A magnetic beads.
Every Protein A molecule can bind two Fc fragments, which can then link two MBDs each. According to our very elaborate estimates, that means that each bead packs a whole boatload of methyl-DNA binding ability that gives extremely low backgrounds without hiding it’s highly sensitive side compared to other MBD-based kits.
- EpiMark™’s MBD2a gobbles up methyl CpGs like Pac-Man, but without the wacky sound effects.
EpiMark™ Puts Time On Your Side
Sure, you can spend 4-6 hours, or longer, on your DNA methylation enrichment if you like, but EpiMark™ makes that a thing of the past. A smoothed out protocol and dialed in reagents will have you clocking in methyl-enrichments in 2 hours flat…leaving plenty of time to make the lab happy hour.
The Road to Enrichment
Find out how the fast and sensitive EpiMark™ DNA Methylation Enrichment Kit can help bump your DNA methylation studies up a notch at the New England Biolabs website.