Little-by-little, step-by-step, and drop-by-drop, we are beginning to appreciate the vital importance of intracellular liquid-like droplet formation to fundamental mechanisms such as epigenetic inheritance and heterochromatin domain formation. Liquid-like droplets aid these processes by biological “phase-separation” or the selective concentration of some molecules into a small intracellular area and the exclusion of others. Excitingly, two new […]
EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.
Writing your first grant proposal? Optimizing that tricky Western blot? Programming an old PCR machine? Only a few things are more complex than our current understanding of the epigenetic links between aging and tumorigenesis, but this has not stopped a few valiant labs from doubling down and busting a few paradigms while they are at […]
Apart from the ever rising and falling measurements of one’s waistline and bank balance, the three-dimensional (3D) chromatin conformation of the mammalian genome is one of the most dynamic and least understood factors in a scientist’s life. Luckily, the development of new high-definition techniques and enhanced computational analyses are helping us to understand how the […]
In today’s world, where choices are a plenty, alternative is a fashionable choice. When it comes to genomic imprinting, traditionalists swear by DNA cytosine methylation (5mC); however, sometimes imprinting turns to alternative epigenetic marks. Genomic imprinting is typically driven by 5mC at imprinting control regions (ICRs), where it represses the expression of the marked allele […]
Life’s full of experiences that often seem like a coin toss. Should you go the gym or feast on some sushi? While the epigenetic mechanisms behind the outcomes of these two events may seem quite different at first, when considering the epigenetics of sperm, it turns out they’re two-sides of the same coin. Intergenerational Effect […]