It’s December, the time of year when much of the States is blanketed in a frosty mantle of the white stuff. But as recently reported in Molecular Cell, the ACA45 RNA appears to have pulled the ultimate snow job. Nikolaus Rajewsky, Gunter Meister, and colleagues revealed that ACA45, which was previously thought to function exclusively […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
What makes some tumors as gentle as purring kittens and others of the same cancer type as ferocious as saber-toothed tigers? A miRNA (miR-101) was recently shown to take a bite out of cancer by inhibiting the EZH2 histone methyltransferase. The study by Arul Chinnaiyan and co-workers at the University of Michigan Medical School, the […]
Do you remember the name of your fourth-grade teacher? How about what you had for lunch last Thursday? Highschool Prom date? Yeah, we went stag too, but if you’re having a hard time remebering key events, ncRNAs may be to blame! The human brain expresses high numbers of ncRNAs, and mounting evidence indicates important contributions […]
Unfortunately, the KISS principle (‘keep it simple, stupid’) doesn’t apply to chromatin. Although we’d like to think that certain histone modifications are always “good” for gene transcription and others are invariably “bad,” Barbara Panning and co-workers at the University of California San Francisco have found that in embryonic stem cells (ESCs), the transcriptional outcome of […]
Everywhere you look, be it Science or Nature, US Weekly (OK, not quite), silencing by ncRNAs is making headlines. But the targets and mechanisms of this silencing are not always clear. A recent report by Peter Fraser and co-workers at The Babraham Institute (UK) and several other universities and centers in Japan and Europe has […]