For the last few years, DNA has cornered the methylation market as the Apple of epigenome editing tools, but a newly developed CRISPR-Cas13 system has epigenetic investors buying stock in RNA editing! 6-methyladenosine (m6A) is the most abundant RNA modification, and even though we know it’s involved in chromatin accessibility, RNA splicing and repairing damaged […]
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Search Results for: m6A
Epitranscriptomic Editing: m6A RNA Methylation Tools Join the CRISPR Arms Race
CRISPR-Cas9 genome editing has revolutionized not only the way genomes are modified, but thanks to deactivated Cas9 (dCas9) and it’s growing arsenal of effector domains, it has also provided the tools needed for the epigenome editing revolution. However, to date, the tools to modify RNA itself have been lagging behind in the epigenome editing arms […]
Existential Epigenetics: Deciphering the Where, the Why, and the How of m6A and m6Am mRNA Methylation!
Can we break the speed of light? Is the universe infinite? What is the answer to life, the universe, and everything? At least two of these questions have fascinated physicists and philosophers for decades, but the questions weighing heavy on their minds of the existential epigeneticists among us relate to something a little different: the […]
Neurons Make the Most of m6A mRNA Methylation
Move over DNA methylation, take a seat histone modification, it’s time to make room for RNA methylation. When you think of the importance of epigenetics to brain function and cognition, you probably think of well characterized changes DNA methylation, histone marks, and ncRNA. Well you better make some room in your own neural networks, because […]
Running Around in Circles to Understand N6-methyladenosine (m6A)
While most studies on the N6-methyladenosine (m6A) RNA modification have been on the straight and narrow, the research trajectory taken by the labs of Cosmas C. Giallourakis and Alan C. Mullen will have you running around in circles! More specifically, Chan Zhou and Benoit Molinie (along with their tight circle of friends) sought to discover […]