Some say the bigger the better, while others believe it’s what you do with it that counts! Now, a study reports that the most recent iteration of EPIC DNA methylation (900K EPIC v2) microarrays – which supercharges your insight by taking in both many more informative CpGs and additional chromatin features – supports the efficient […]
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Search Results for: DNA Methylation
DNA Methylation Editing Provides Evidence for Transgenerational Epigenetic Inheritance in Mammals
While we have become familiar with the link between DNA methylation and disease, an exciting epigenetic editing study now reports how DNA methylation contributes to transgenerational epigenetic inheritance in mammals and influences disease-associated traits across generations! In their previous study, a talented team led by Juan Carlos Izpisua Belmonte at the Salk Institute for Biological […]
eBook: Epigenetics & DNA Methylation
One of the longest-known and most studied epigenetic markers is DNA methylation, which can regulate gene expression and genomic organization in nearly all organisms. In eukaryotes, the primary modification of DNA is found in cytosines (C), where DNA Methyltransferases mediate the transfer of a methyl group to cytosines, converting them to 5-methylcytosine (5-mC), minor modifications […]
Placental Proxies: A Shared DNA Methylation Profile Between cffDNA and Brain
When you’re looking to access the latest and greatest publications, your VPN is the proxy you need. But now, there’s a new proxy in town to help with your quest for neurodevelopmental epigenetic information: Placenta and the cell free fetal DNA (cffDNA) that originates from it. A dynamic duo of papers from the lab of Janine LaSalle (UC Davis […]
No Cells? No Problem! How Cell-Free DNA Methylation Profiles May Guide Cancer Management
When set the monumental task of studying how the epigenetic mechanisms underlying tumorigenesis, isolating a cell sample usually represents your first analytical port of call; however, research now suggests that liquid biopsies of a patient’s blood may provide a wealth of information from cell-free DNA. Furthermore, widening this approach to DNA methylation analysis may also […]