Too Much Tau Over Relaxes Chromatin in Neurons in Aging and Alzheimer’s BrainsFebruary 3, 2019Taking a break can be a great thing for our aging brains, it gives us a chance to unwind and open ourselves up to new ideas. However, it’s possible to have too much of a good thing, where overly relaxed chromatin can wreak havoc on an aging neuron and drive pathological changes! One of the […]
Perturb-ATAC: Single-Cell Multiplex CRISPR Screening of Chromatin Regulatory NetworksJanuary 30, 2019Feeling perturbed by the limitations of current chromatin assays? Looking for something high throughput that combines multiplexed genome editing with single cell resolution of open chromatin? Well look no further than Perturb-ATAC. The lab of Paul Khavari (Stanford, California) sought to address the above challenges with simultaneous measurements of perturbations and chromatin state in single […]
LncRNA-mediated Trisomy Silencing: Is the Reversal of Down Syndrome-associated Disease Just an Epigenetic Switch Away?January 24, 2019While “the rule of three” principle may make three the magic number for fairy tales and Hollywood blockbusters, trisomy of chromosome 21 causes Down syndrome (DS) and leads to the development of a range of severe associated disease and disorders in affected patients. However, research out of the laboratory of Jeanne B. Lawrence (University of […]
Teasing Apart the Brain: DNA Methylation Maps of Healthy Neurons Implicate Brain Region Differences in Psychiatric DisordersJanuary 24, 2019While conducting epigenomics research, we are often faced with a number of brain teasers. To solve these cognitive conundrums, many of us turn to diseases and disorders to learn about healthy conditions. However, the methylation maestros in the labs of Andrew Feinberg and Kasper Hansen at John Hopkins University (Maryland, USA) now demonstrate the utility of […]
Monkey Memes: Social Status Epigenetically Primes a Stress-Responsive Chromatin ProfileJanuary 15, 2019Are you constantly checking your Twitter/Instagram/Reddit feeds for the newest memes and best cat videos to share for the most likes? Well, don’t spend too much time stressing over your social media status; especially if you are a rhesus macaque, because new research suggests your immune cells might take a major epigenetic hit if you’re […]
