Abstract Elucidation of molecular mechanisms of genome functions such as transcription and epigenetic regulation requires identification of components mediating the genome functions. To this end, we recently developed the locus-specific chromatin immunoprecipitation (ChIP) (locus-specific ChIP) technologies to identify molecules interacting with a given genomic region of interest in vivo. Locus-specific ChIP consists of insertional ChIP […]
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Search Results for: ChIP
Tag-ChIP-IT® Kit
The Tag-ChIP-IT® Kit offers a method to perform chromatin immunoprecipitation (ChIP) on transcription factor sequence variants, mutations and truncations without the need for protein-specific antibodies. Simply create an expression construct containing the protein of interest in-frame with a C-terminal AM-tag. Active Motif’s unique AM-tag sequence is specifically designed to work in ChIP. It has minimal […]
Hearts on Chips
Chips, in most incarnations, are bad for the heart. Whether you’re frying them, baking them into cookies, or carrying one on your shoulder, chips are not cardiologist-approved. A new paper from Kevin Healy’s lab aims to mend this relationship with a microfluidic chip that is able to coax human induced stem cells into beating 3D […]
Webinar: A Step-by-Step Guide to ChIP-Seq Data Analysis
In this webinar, Dr. Xi Chen takes publicly available real ChIP-seq data sets to show you how to perform ChIP-seq routine analysis using a combination of different online tools available. This provides an opportunity for bioinformatics beginners and wet-lab biologists who do not have much experience with unix operating systems to have an idea about […]
Two New Players for Better Differential Peak Detection in ChIP-Seq
Sometimes bioinformatics can seem a bit mystical, particularly when a tool arrives that makes you wonder what you were wasting your time doing before it. ChIP-seq is no stranger to this world and as a driver of a large proportion of epigenomic experimentation we’re also no stranger to the challenges of processing ChIP-seq data and peak calling. One of […]