The search is on to figure out a role for the recently discovered 5-hydroxymethylcytosine (5hmC) base. While it’s still up in the air if 5hmC will play a main character or just be cast as an extra , this new study in Nature ties the mysterious modification to a demethylation pathway, regulated by Tet proteins, […]
- "ChIP"
Search Results for: ChIP
DNA Methylation Takes a Back Seat To Histone Mods in miRNA Regulation
DNA methylation has long been considered a key epigenetic driver in transcription, but lately histone modifications have been stealing some of the regulatory thunder. Histone mods like H3K4me3, H3K27me3 and H4 acetylation have shown researchers they’re not afraid to get conrolling when it comes to miRNA transcription either. Researchers from the Institute of Genetics and […]
Forgetting Things? Better Acetylate Your H4K12
Ever feel like you’re forgetting things more often as you get older? Little things like where you put your keys or why you walked into the cold room (not that we would know what that’s like – as far as you know!) can turn into huge mysteries. Researchers now think they’ve pin-pointed why this happens, […]
microRNA Targeting mRNAs: More Exceptions Than Rules
Up to now, all miRNAs have been assumed to work the same way when it comes to finding their mRNA targets, but a new paper shows that miRNAs behave more like rugged individualists in how they function. Researchers from the University of Kentucky broke out the RIP-Chip method (Argonaute, aka AGO, co-IP assays coupled with […]
CpG Islands Tackle Chromatin Remodeling Project
Researchers have known about CpG Islands (CGIs) for decades, but there are still more questions than answers when it comes to this heavily studied genomic real-estate. Hypermethylated CGIs seem to get a lot of attention for their apparent involvement in transcriptional silencing, but most CGIs stay unmethylated. So what’s going on in these unmethylated CGIs? […]