Pseudouridine (Ψ) is not only the most abundant post-translational modification (PTM) of RNA in all organisms, but it is also amongst the first discovered, way back in the futuristic 50’s, where it was deemed the 5th nucleotide of RNA. Ψ doesn’t discriminate against cellular functions or evolutionary distinct species. And while studied intently in rRNA […]
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Important DNA Methylation Factors
DNA methylation is the process through which a methyl group is added to DNA nucleotides. The most common form of this occurs at the 5-carbon position of cytosine (5 methylcytosine or 5mC). DNA methylation can stably alter the gene expression of a cell, which may direct processes like stem cell differentiation and genomic imprinting. DNA […]
Epigenetics Special Issue: Non-coding RNAs in Epigenetic Regulation
From the very beginning, EpiGenie has held a place in our hearts for non-coding RNAs. That’s why we were stoked to see that the Landes journal Epigenetics dedicated an entire issue to the enigmatic and always interesting little transcripts. The Epigenetics: Special Focus on Non-coding RNAs in Epigenetic Regulation issue features a boatload of reviews […]