While the DNA editing function of CRISPR/Cas9 systems may appear to hog the limelight, we believe that a new SunTag approach for CRISPR/Cas9-mediated induced pluripotent stem cell (iPSC) reprogramming via epigenome editing deserves its day in the sun! The exciting reprogramming strategy utilizes an endonuclease dead Cas9 (dCas9) fused to a repetitive protein scaffold known […]
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Stem Cell Research Headlines
Get all the latest highlights from the literature and special features covering trending stem cell research and applications.
During early embryonic development, our genome lets down its DNA methylation defenses and becomes vulnerable to rebellious transposable elements (TEs). However, those rebel scum are quickly met with a barrage of endogenous short interfering RNAs (endosiRNAs), all before they realize even realize that “It’s A Trap!” The mechanism of this cunning tactic employed by our […]
Presumably after a day spent in a local tavern instead of writing and editing verse, the famous Scottish poet Robert Burns noted that “The best laid schemes of mice and men, Often go awry”. However, a new study of genome editing in the embryos of mice and men led by Kathy K. Niakan (Francis Crick […]
While cocktails and embryonic development usually don’t mix well, a cocktail of three transcription-activator-like effectors (TALEs) has just shaken up our understanding of the role LINE-1 retrotransposons during early embryonic development. LINE-1 activation had been considered a consequence of developmental processes, but now a talented team from the lab of Maria-Elena Torres-Padilla at the German […]
It’s not how big it is, it’s what you do with it that counts. Here at Epigenie, we don’t think that size matters, as evidenced by our excitement over studies showing that small RNAs in sperm can mediate huge intergenerational effects related to paternal exercise and diet! Now, a fascinating study from the lab of […]