Organismal development and cellular differentiation are driven by the timely orchestration of gene expression, alteration of which can result in diseases including cancer. Genome-wide approaches have revealed an unprecedented complexity of RNAP II regulation by chromatin and non-coding RNAs.
This symposium will bring together experts in RNAP II transcription, splicing, chromatin and RNA biology to share their most recent discoveries on the molecular events controlling gene expression during development and disease, with the main goal being the identification of key regulatory steps that could be exploited for therapeutic purposes.