Having trouble maintaining that New Year’s resolution to stay fit? Then you might want to ask a yeast for some advice: it turns out some of their evolutionary fitness is tied to maintaining DNA methylation with a methyltransferase for millions of years. DNA methylation is a common genomic modification, present in all life and prevalent […]
- DNA Methylation
Some of the best superheroes are born out of a mutational event. It’s how Peter Parker became Spiderman, how Bruce Banner turned into the Incredible Hulk, and where the X-Men derive their powers. It just goes to show that mutations aren’t always a bad thing — a point exemplified by the new superhero team in […]
A weekend away with a book of poetry, a mountain biking holiday, or perhaps a daring jewel heist……whatever your idea of a fun weekend is, a well-laid out, precise set of instructions usually help; in short, you need a plan! In the gastrulating mouse embryo, precise epigenomic and transcriptomic instructions dictate the differentiation of pluripotent […]
It’s clear that humans and mice have taken very different evolutionary paths, but new research suggests that transcription from long terminal repeat retrotransposons (LTRs), which are endogenous retroviral elements that can induce DNA methylation in oocytes, may have acted as guiding lights along the forks in the road. Besides the obvious differences in size, furriness, […]
Dr. Guillaume Bourque from McGill University discusses his lab’s bioinformatic research examining the epigenomics of non-coding DNA sequence variants at the 2019 joint CEEHRC/IHEC meeting.