While stories of Mom meeting Dad often leave their mark on a family, and sometimes a nation, the plot has now thickened thanks to new findings showing that Mom’s DNMT3A leaves its mark on Dad’s genome in the early embryo. DNA methylation in the male germline undergoes massive changes during preimplantation. High paternal DNA methylation […]
- Chromatin
Turning the Spotlight on Extraordinary Epigenetics Content
Our sponsors help keep the lights on, the Wi-Fi humming, and our epigenetic content flowing to your screens each week. And while we may be a tad biased, we want to turn the spotlight on the range of highly useful and always educational epigenetics content from these websites that you should check out! Dovetail Genomics […]
Special Multiomics Feature: Combinatorial DNA Methylation and Chromatin Assays Serve Up New Insight
Combinations of old favorites can be even tastier than the sum of their parts. Who doesn’t leave peanut butter and jam, chips and dip, and DNA methylation and chromatin assays? While they sound appetizing, those last two aren’t quite as easy to get together. Many assays have been developed in the past to combine ChIP […]
Long-Sperm Effects: THC and Nicotine Have A Lasting Impact on Bivalent Chromatin and Autism Genes
While some fathers planning a family may be left in a bivalent state when deciding about smoking cannabis or nicotine, new research has cleared the air. THC and nicotine both prime an autism spectrum disorder profile in sperm through altering DNA methylation within bivalent chromatin states. In their seminal paper, researchers from the lab of […]
Multi-omic Analyses Highlight an Epigenetic Treatment Strategy for Early-stage Alzheimer’s
Given the unfortunate failure of many treatment strategies for late-stage Alzheimer’s disease, researchers recently sought to gain some fresh new perspective from multiple angles by mounting a three-pronged transcriptomic, proteomic, and epigenomic attack to decipher the mechanisms controlling disease progression. Excitingly, the team behind this study now highlight the possibility of an early-stage epigenetic therapy […]