While many see chit-chat and gossip as a tiresome but inevitable part of life, epigenetic eavesdropping has recently demonstrated that the tight regulation of gene expression relies on some close-quarters methylation crosstalk! The molecular back-and-forth uncovered occurs between the transcription elongation-associated H3K36me3 histone modification and the prevalent and essential post-transcriptional N6-methyladenosine (m6A) mRNA modification. So […]
Ever get that feeling that you forgot something? Well maybe you did, but it doesn't have to be recent epigenetics research if you scope out our Headlines each week.
Watch out epigenomic evil-doers, histone H3 has a new sidekick to help it keep gene regulation in shape. By day, serotonin can be found in its traditional role as a neurotransmitter; being released by cells of the nervous system and binding to specific receptors to impact a wide range of functions, from cognition to gut motility. […]
While trying to uncover the mysteries of the DNA methylation, a lot of BS is often required. And no, we’re not talking about workplace politics but rather sodium bisulfite (BS) conversion. Thankfully, the labs of Chun-Xiao Song and Benjamin Schuster-Böckler at Oxford University (UK) have developed a new “BS-free” approach to uncover the secrets of the […]
When it comes to brushing, whether it’s your teeth or a cheek swab sample, proper technique is important. Your dentist may have already told you not to brush you teeth too hard, but it turns out how you collect a cheek swab is also important. Buccal epithelial cells are perhaps the most clinically accessible tissue […]
While many prefer matters to be straightforward, some prefer to think “outside the box” and conjure up an alternative to the norm. Cancer cells are much the same; while most remain on the straight and narrow and employ the telomerase holoenzyme complex to maintain their telomeres, a significant fraction go their own way and use […]