Features

Features

EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.

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eBook: Epigenetics & DNA Methylation

November 21, 2022

One of the longest-known and most studied epigenetic markers is DNA methylation, which can regulate gene expression and genomic organization in nearly all organisms. In eukaryotes, the primary modification of DNA is found in cytosines (C), where DNA Methyltransferases mediate the transfer of a methyl group to cytosines, converting them to 5-methylcytosine (5-mC), minor modifications […]

Can New RNA Modification Profiling Tools Help in Your Epitranscriptomic Bid for Glory?

November 21, 2022

Two new sequencing methods may just make your day if you happen to be bidding for glorious insights into the epitranscriptome. Inspired by the bisulfite conversion used to assay DNA methylation, BID-seq and GLORI now enable single-nucleotide transcriptome-wide profiling of two crucial RNA modifications – N6-methyladenosine (m6A) and pseudouridine (the C5-glycoside isomer of uridine). RNA […]

Single-Cell Spatial and Multimodal Upgrades to ATAC-Seq Speed Up Your Chromatin Insights

October 9, 2022

Need to get swiftly up to date with recent advances to the assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-Seq) technique? Well, slow down and read on for the latest single-cell spatial and multimodal updates to your chromatin toolbox! Our first study gives us a quick lowdown on Spatial-ATAC-seq, a technique to capture spatial chromatin […]

Placental Proxies: A Shared DNA Methylation Profile Between cffDNA and Brain

September 27, 2022

When you’re looking to access the latest and greatest publications, your VPN is the proxy you need. But now, there’s a new proxy in town to help with your quest for neurodevelopmental epigenetic information: Placenta and the cell free fetal DNA (cffDNA) that originates from it. A dynamic duo of papers from the lab of Janine LaSalle (UC Davis […]

eBook: Epigenetics of COVID-19

September 22, 2022

COVID-19 has been one of the biggest public health issues in recent history and has changed the daily lives of almost everyone on the planet. Many researchers, biotechnology and pharmaceutical companies have been working around the clock since the novel coronavirus outbreak started to try to develop new tools to test for and treat the […]

Now In Print! – New Technologies Leave their Mark on Imprinting Control Regions

June 19, 2022

Genomic imprinting typically lets our parents leave their mark on our genomes; however, new technological advances are now allowing us to leave our mark on imprinting! The first of our epigenetic exposés that went into print reports on how multiple modalities uncovered complex epigenetic crosstalk that regulates allele-specific gene expression at potential imprinting control regions […]

Dr. Steve Chan: The Epigenetic Regulation of Breast Cancer

June 9, 2022

Using unbiased ChIP-Rx analyses to discover a novel role for CTR9 in the epigenetic regulation of PRC2 subtype switching in breast cancer Our colleagues at Proteintech hosted a webinar from Dr. Steve Chan from The University of Wisconsin-Madison, who reviewed their recent paper “The transcriptional elongation factor CTR9 demarcates PRC2-mediated H3K27me3 domains by altering PRC2 […]

eBook: Epigenomics of Sperm

June 9, 2022

Some of the most interesting and important epigenetic phenomena occur in sperm. In addition to passing genetic paternal information, experiences and exposures can be encoded in the epigenome and inherited as well. In this EpiGenie ebook, we present summaries of several studies on exploring the role of epigenetic processes in sperm biology. They are divided […]

Webinar: Chromatin Immunoprecipitation (ChIP) Workshop – Dr. Toryn Poolman

February 28, 2022

If you’re new to chromatin immunoprecipitation (ChIP), or you’re thinking about giving it a try, you will want to take the time to watch this webinar first! Our friends at Proteintech put together an excellent workshop led by Dr. Toryn Poolman at University College London that covers a ton of tips and tricks that will […]

A Suite of New Tools to Solve Single-cell Epigenetic Enigmas

December 23, 2021

Welcome explorers of the epigenome! Are you looking for new tools to help answer the toughest of epigenetic enigmas? Then check out this suite of single-cell methods papers from technologically-talented teams led by Aviv Regev (Broad Institute of MIT and Harvard) and collaborators. inCITE into How Transcription Factors Shape In Vivo Gene Expression A collaboration […]