It seems that everyone has MeCP2 on the brain – as evidenced by its starring role in two new Molecular Cell papers – but it’s in your brain too! The MeCP2 protein is essential for neuronal function and consistent with this, loss-of-function mutations in MeCP2 cause the neurodevelopmental disorder Rett syndrome. Unfortunately, because MeCP2 acts […]
- Features
Features
EpiGenie Features call out new Methods, provide Insights into emerging trends, or sometimes just share technical tips from the experts in our community.
A Perfect Harmony: Orchestrating Joint Chromatin Conformation and Methylome Mapping in Single Cells
If a better understanding of gene regulation is music to your ears, then tune in for the latest developments in single-cell epigenomics. It is well established that both DNA methylation and higher-order chromatin structure play crucial roles in development, differentiation and disease, and there are readily available technologies for both (whole-genome bisulfite sequencing and chromatin […]
Webinar: The Epigenetics of the Exposome and Aging – Paul G. Shiels
Don’t miss this great webinar detailing some of the latest discoveries about the role of epigenetics in aging. Aging results in a gradual and progressive loss of physiological functions and physical abilities over time. Overcoming the growing burden of age-related issues is one of the greatest challenges facing modern society. These issues are leading to […]
The Tn5 Transposase Takes Single-cell ChIP-Seq to the Next Level
It’s never good to see someone lagging behind the rest, but while stepwise developments to single-cell chromatin immunoprecipitation and subsequent parallel sequencing techniques (ChIP-seq) have led to gradually improved yields and increased sensitivity with reduced numbers of cells since the first report of a single-cell ChIP protocol, we still lack widely-applicable and low-cost methods to […]
Existential Epigenetics: Deciphering the Where, the Why, and the How of m6A and m6Am mRNA Methylation!
Can we break the speed of light? Is the universe infinite? What is the answer to life, the universe, and everything? At least two of these questions have fascinated physicists and philosophers for decades, but the questions weighing heavy on their minds of the existential epigeneticists among us relate to something a little different: the […]