Changes in epigenetic regulation are hallmarks of the transition from normal to cancerous cells. Exploration of the role of epigenetics in cancer has proven to be informative for better understanding both cancer and epigenetic mechanisms. In this EpiGenie ebook, we present summaries of several studies on exploring the role of specific epigenetic processes in cancer. […]
- Cancer Epigenetics
If You Like Piña Coladas, and tRNAs: Unique Relationships Between tRFs and mRNAs
It can be tough to find a significant other that checks all the boxes: smart, funny, and into epigenetics. But if you think your relationship is tough to figure out, just wait until you see the relationship between tRNA derived fragments and mRNAs. New research from the lab of Isidore Rigoutsos (Thomas Jefferson University, USA) […]
Two “Suite” Tools for Tackling Big Data in Cancer Epigenomics Analyses
With all the new datasets available, making sense of epigenomics data can be like finding a needle in a hayfield, let alone a stack. Studies of epigenetics in human complex disease have been greatly aided by larger and larger databases, but identifying meaningful biological relationships using these databases is challenging given their size. Cancer studies […]
Astrocyte microRNAs Welcome Metastatic Cancer Cells to the Brain
If asked what to bring on a fishing trip in winter, your answer probably wouldn’t be a bathing suit and sunblock. Likewise, when cancer cells metastasize, they need the right equipment to reside in unfamiliar organs; in other words, they must adapt their expression programs to accommodate their new microenvironment. How they do this is […]
Resistance is Futile: Epigenetic Therapy Makes Cancer Cells Defenseless
A team of American scientists have shown that an epigenetic therapy might hold promise for combatting drug resistance in cancer. Cancer cells are masters of drug evasion and adept at using alternative pathways to give them an edge during treatment, complicating many therapeutic approaches. Overcoming drug resistance in cancer cells, would save millions of lives […]