If you’re underperforming at work, you might end up with a rejected paper, failed experiments, or an angry boss. However, this isn’t so bad when compared to how mutated DNMT3A underperforms in its role as a DNA methyltransferase, since that can result in a pathogenic overgrowth known as Tatton-Brown-Rahman syndrome (TBRS). Despite DNMT3A’s known role […]
- Cancer Epigenetics
Heterochromatin Finds an Alternative Way to Lengthen Telomeres
We recently advised our readers to “think different” when it came to the epigenetic control of maintenance in alternative lengthening of telomeres (ALT) cells, and now, a team of “out-of-the-box” thinkers from the lab of Jérôme Déjardin (Université de Montpellier, France) have described an unconventional link between ALT and telomeric heterochromatin formation. Previous results have […]
eBook: Cancer and Epigenetics
Changes in epigenetic regulation are hallmarks of the transition from normal to cancerous cells. Exploration of the role of epigenetics in cancer has proven to be informative for better understanding both cancer and epigenetic mechanisms. In this EpiGenie ebook, we present summaries of several studies on exploring the role of specific epigenetic processes in cancer. […]
If You Like Piña Coladas, and tRNAs: Unique Relationships Between tRFs and mRNAs
It can be tough to find a significant other that checks all the boxes: smart, funny, and into epigenetics. But if you think your relationship is tough to figure out, just wait until you see the relationship between tRNA derived fragments and mRNAs. New research from the lab of Isidore Rigoutsos (Thomas Jefferson University, USA) […]
Two “Suite” Tools for Tackling Big Data in Cancer Epigenomics Analyses
With all the new datasets available, making sense of epigenomics data can be like finding a needle in a hayfield, let alone a stack. Studies of epigenetics in human complex disease have been greatly aided by larger and larger databases, but identifying meaningful biological relationships using these databases is challenging given their size. Cancer studies […]