The Epigenetics of Exercise: Acvr1c Improves Learning and MemoryJuly 24, 2024Exercise can boost your mood and improve heart and bone health. Now, a talented team uncovers the epigenetic mechanisms behind another good reason to hit the gym. Working out can help with learning and long-term memory via Acvr1c, a member of the TGF-beta family. Gym rats—er, exercising mice—can learn under “subthreshold training” conditions after a workout, […]
PaleoHi-C Makes a “Mammoth” Genome Architecture DiscoveryJuly 22, 2024Certain scientific findings may be considered colossal or even epic in scale; however, few compare to a “mammoth” new study describing the three-dimensional genome architecture of preserved cells from a 52,000-year-old animal skin sample thanks to a primeval-sounding yet cutting-edge technique known as PaleoHi-C! Epigenetics research goes pre-historic! A veritable “stampede” of researchers led by […]
Age-related Chromatin Remodeling: Loss of Epigenetic Info or the Hijacking of Maturation?July 22, 2024In this world nothing can be said to be certain, except Spain winning at football and age-related chromatin remodeling! While this remodeling was thought to drive aging via the loss of epigenetic information, new research provides evidence for the “hijacking” of developmental maturation via activator protein 1 (AP-1)-activity as a major player. Surefire researchers “captained” […]
Attacking Aging with TAC: A TERT Activator CompoundJuly 8, 2024Aching joints and wrinkled skin are an unwelcome part of aging, but in the future, you might be able to avoid arthritis medications and cosmetic procedures by getting a shot of TERT activator compound (TAC). A young-at-heart team identified this small molecule, which increases transcription of a telomerase subunit called TERT. The upshot is that […]
A CHARMing Epigenetic Editor Enchants Endogenous DNA Methylation Machinery to Pause Prion DiseaseJuly 8, 2024While George Clooney or Cate Blanchett exude a degree of charm, a captivating new epigenetic advance may outdo them both! A new study now describes a compact epigenetic editor known as “CHARM” that engages the cell’s own DNA methylation machinery to stop a fatal neurodegenerative disease in its tracks. A charismatic crew guided by Sonia […]