While we hope that any silly errors and childish pranks of our formative years don´t follow us into adulthood, it now seems that certain experiences during early development are indeed carried into adulthood without our knowledge, where an activating trigger can lead to trouble and strife! Specifically, exposure to any number of environmental stressors during […]
- Aging
Disrupted LADs Drive Epigenetic Alterations in Human Early-onset Aging
The “driver” represents a crucial part of a successful Formula One team, a decent score at golf, and even a well-planned bank heist (!), and working out those factors that drive the onset of various diseases and disorders may provide critical mechanistic insight and even aid the development of novel therapeutic approaches. In the early-onset […]
A Rewired Metabolism Links the Aging Epigenome to Vision Loss
They say hindsight is 20/20, but for those of us looking over at a lifetime of memories, things might seem a little blurrier through our aging eyes. That’s because, unlike the fine wines, delectable whiskies, and smelly cheeses that we love to catabolize, the human epigenome tends not to age very well and a wide […]
Not Aging Gracefully? Two Epigenetic Regulators May be to Blame
In the last 50 years, there has been a ~20% increase in global life expectancy but interestingly, there has not been a corresponding increase in the number of healthy years lived. Lubin Jiang and Shi-Qing Cai at the Chinese Academy of Sciences (Shanghai, China) sought to understand that disparity by examining the genetic factors involved […]
Single Cell Analyses Reveal How Epigenetic Drift Makes Stem Cells Age Badly!
While cheese and wine (and whisky!) all get better with age, the human body fares less well! Although partaking in too many culinary delights hardly helps, studies have established the reduced number and activity of stem cells as a cause for the age-related deterioration of various tissue types. With this in mind, a talented team […]