Transcription of the eukaryotic genome is not only driven by the cis regulatory elements embedded in the linear DNA sequence but also by the way chromosomes fold in the three-dimensional (3D) nuclear space. Growing evidence has pointed to a key role of the 3D genome architecture in gene regulation and human disease. However, the details of dynamic chromatin organization in different cell types remain opaque. Additionally, how chromatin organization shapes the gene regulatory program and influences disease pathogenesis has not been fully elucidated. The major objective of this conference is to accelerate the study of 3D genome organization particularly with regard to gene regulation and human disease. The conference program will highlight recent technological advances, such as omics-based and imaging-based technologies. The conference will also discuss emerging concepts of chromatin organization and its role in cancer and other human diseases. Finally, the conference program will provide workshops and tutorials on the latest computational tools and data resources for 3D genome analysis. Because epigenetic processes such as chromatin remodeling and DNA methylation are intimately linked to the 3D genome architecture, this conference will be held jointly with the Keystone Symposia conference on “Epigenetics and Human Disease”, further enhancing the goal to stimulate cross disciplinary interactions among researchers from genomics, epigenomics, computational biology, cell biology and molecular biology fields.
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- 3D Genome: Gene Regulation and Disease
3D Genome: Gene Regulation and Disease
Keystone Symposia - 17 Mar 2019
Summary
Topics
Details
Meeting Summary
Topics Include
- 4DN Nucleome Consortium Resources
- Single Cell Analysis of Genome Architecture
- Analysis of 3D Genome with Advanced Microscopy
- ENCODE Consortium Resources
- Chromatin and Epigenetics
- 3D Genome and Gene Regulation
- Roundtable Discussion: Women in Science
- Genome Architecture and Development
- Computational Analysis of 3D Genome
- Roundtable Discussion: Careers in Industry
- 3D Genome and Disease
Meeting Details
Date | 17 Mar 2019 |
Location | Fairmont Banff Springs Banff, Alberta, Canada Get Directions |
Organizers | Bing Ren, Ana Pombo and Joseph R. Ecker |