SIMPLE-seq Collaborates Chemistries to Report Single-Cell 5mC and 5hmCFebruary 20, 2024Collaborations work best when team members’ abilities complement each other. That’s what makes SIMPLE-seq work so well—it’s a simple, easy combination of two methods that complement each other to provide both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) datasets in one experiment in single cells and molecules. Continuing on the recent theme of methods that report both 5mC […]
Relax and Let NanoSPA Analyze m6A and Ψ RNA Mods for YouFebruary 20, 2024We could all use a spa day once in a while, so light some lavender-scented candles, take a deep breath, and let NanoSPA analyze the RNA modifications in your samples. This new nanopore sequencing analysis pipeline provides data on both N6-methyladenosine (m6A) and pseudouridine (Ψ) modifications at the same time, reducing stress and saving time. Instead […]
Making a Connection – Lactate Epigenetically Links Metabolism and Gene ExpressionFebruary 19, 2024Falling in love, kicking a football, and cell identity changes driven by metabolic reprogramming all have one thing in common – making a connection is vitally important! Now, Â a well-hooked-up new study reveals how lactate epigenetically links metabolism to the activation of a gene regulatory network that controls embryonic development. A plugged-in team of researchers […]
TIME-Seq Flies When Constructing Cost-Effective Epigenetic ClocksFebruary 19, 2024If time drags and money disappears when looking at DNA methylation-based epigenetic clocks, you are “in time” to hear of a newly described efficient and cost-effective bisulfite sequencing approach! Time flies – but money does not – with “tagmentation-based indexing for methylation sequencing” or TIME-seq! An on-time team led by David A. Sinclair (Harvard Medical […]
eBook: New & Novel Methods for Epigenetic AnalysisFebruary 7, 2024Epigenetics is not new, but methods used for analysis certainly can be! In this eBook, we take a look at, and present in a simple format, some of the hottest new methods for researchers looking at DNA Methylation, RNA modifications, Chromatin and Gene Regulation. Topics Include: Differential Methylation Data Are Quick, Easy, and Inexpensive with […]